A trivia tournament of 16 teams on VH1, The World Series of Pop Culture rules are outlined at the start of each show:

"The game is played in a best-of-five-rounds format. After a category is announced, each team will send a representative to the microphone, who must play for the entire round. The player who answers the most questions correctly, out of a possible six total questions, in the round, will knock out his or her opponent. The first team to knock out all three members of the opposing team will be declared the winner and move on in the tournament."